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ѪHE4CA125ѳеӦüֵ
ʱ: 2019-11-1 13:45:26 Դ: : :35

  лӢ

ҽԺ ƶ    545005

ժҪĿ  ̽Ѫ帽غףHE4 ѳԭCA125ѳеӦüֵ ռ78ѳߺͬڽߵѪ걾໯ѧֱѪHE4CA125ˮƽ ѳߵѪHE4CA125ˮƽڶ飻ѪHE4ѳж׼ȷȾCA125ߣѪHE4ѳͬڱͳѧ壨p<0.05HE4CA125ϼѳжȡ׼ȷȡHE4CA125ϼѳЧʡ

ؼ: غ4 CA125 ѳ

The value of serum HE4 combined with CA125

in the diagnosis of ovarian cancer

Wu Baixiu     Xie Hongying

(Liuzhou Workers' Hospital, Department of Gynecology, Liuzhou 545005, China)

        Abstract: Objective To investigate the value of human serum epididymis protein 4 (HE4) and human ovarian cancer antigen (CA125) in the diagnosis of ovarian cancer. Methods Serum samples from 78 patients with ovarian cancer and healthy subjects were collected. The serum levels of HE4 and CA125 were measured by Abbott Chemiluminescence Analyzer. Results The levels of serum HE4 and CA125 in patients with ovarian cancer were significantly higher than those in the control group. The sensitivity, specificity and accuracy of serum HE4 in diagnosing ovarian cancer were higher than those in CA125. The difference of serum HE4 expression in different stages of ovarian cancer patients was statistically significant. (p<0.05); combined detection of HE4 and CA125 can improve the sensitivity, specificity and accuracy of ovarian cancer diagnosis. Conclusion Combined detection of HE4 and CA125 can improve the diagnostic efficiency of ovarian cancer.

Key words: epididymis protein 4; CA125; ovarian cancer; joint diagnosis

ѳһַʺʽϸߵĸƶ֮һʽӹӹ尩ѳѳƤǸ฾λŮвѳСǻ֮ڣȱ͵ٴ֢״ڷ֣Ŀǰٴֵѳɢ踹ǻ٣ѳԵΪҪCA125ͳ־ѳһԣҪCA125ѳҺ԰δֻеʽϸߣҺ԰еʽϵͣһЩԼCA125Ҳ,ǻ֢ѳӹĤλ֢ȣCA125ӦõԼܵ[1]غ4(HE4)һµ־ҲѳҪ̽ѪHE4CA125ѳеӦüֵ

1ͷ

1.1һ

ռԺ20182201810PסԺĻϣռ׷ѳ78ΪܹƺڷųѪѹ֢оίԱʿƶIJѧڱ׼,Т-41-37ƽΪ53.87.9ꡣѡȡͬԱ80Ϊ

1.2

۲Ͷ峿ոȡѪ5mLֹ30Ļ3000r/min10minϲѪ壬-80䱣汸áCA125HE4ΪȫԶѧi2000ԼУ׼ƷΪԭװʹãṩı׼вCA125IJοΧΪ0 - 35U/mLHE4IJοΧǣδŮ<70 pmol/LŮ<140 pmol/LӦIJοΧжΪԡȽ۲CA125HE4ˮƽǷڲ죬CA125HE4Чʡ

1.3 ͳѧ

ϲ SPSS 25.0 ͳѧдþֵ׼ʾt,ÿ飬P <0.05 Ϊͳѧ塣

2

2.1۲Ѫ HE4CA125 ˮƽȽ

۲ѪHE4CA125ˮƽԸڶ飬ͳѧHE4ڹ۲--֮ͳѧ壬CA125ڹ۲--֮ͳѧ 1

Ѫ HE4CA125 ˮƽȽ(`XS)

n

CA125U/mL

CA125

HE4pmol/L

HE4

t

p

t

p

80

10.238.66

8.43

0.02

15.418.66

17.26

<0.001

۲

78

68.6518.63

138.2621.32

-

41

64.2514.26

1.26

0.14

96.3217.24

12.24

<0.001

-

37

71.4119.26

157.3329.66

2.2 HE4CA125 ѳܱȽ

HE4ԱCA12587.50 VS 83.75%HE4жCA12588.46 VS 80.77%HE4ϵ׼ȷȱCA12587.97 VS 82.23%ϵԡжȺ׼ȷ 2

2 HE4CA125TSGF ܱȽ ( % )

CA125

HE4

P

83.75(67/80)

87.50(70/80)

95.0(76/80)

25.14

0.000

ж

80.77(63/78)

88.46(69/78)

93.59(73/78)

17.26

0.001

׼ȷ

82.23(130/158)

87.97(139/158)

94.30(149/158)

40.21

0.000

3

      ѳߣԤϲ֢״ͣԸˮ͡ѪǻʹȷԵıԺڷֲʱȷѳԵΪҪĿǰѳҪʵʩԸѪѧļԵýΪ򵥣ĿǰѳȽŵѪ־CA125HE4CA125ѳȽԵ־ѳԺжȶdz[2-3]ѳҪԴƤ֯ҲһЩԴڼҶ֯ϸ֯ȣCA125Ҷ֯֯УжԽϵҲһЩױCA125Ӳʪؽ׵ȼҲһ̶ȵ뼲Ļ̶ԼԤжһ[4-5]HE4ʱ±ȽŵָHE4Ƥѳ־,ԼٴеĹϵ,ƤѳߵϼԤһļֵ[6]HE4Ҳ󳦰ΰҲһı[7-8]

       оHE4ѳжȺCA125ߣϼѳЧʡҲCA125ѳ--ı޲죬HE4ѳ--ıͳѧ壬ʾHE4ѳķڱCA125һԽԡȻоҲһЩ֮걾Խ٣ֻռҽԺϢзδҪͶԸȷHE4CA125ѳеӦüֵ

       ֮CA125HE4ѳҪߵϼѳЧʡ

ο

[1]˿,,ҦѧȨ.ƤѳѪIGF-1IGF-2CA125ٴֵ[J].ҽҩ,2008,34(11):1183-1184.

[2]֣,,긴, .ѪHE4CA125CA199ϼѳϵٴо[J].ʼҽѧ־,2017,(19):2680-2682.

[3],Ф,ǿ, .־HE4CA125CA199CA153AFPѳеӦüֵ[J].ʼҽѧ־,2017,(19):2718-2719,2722.

[4]Ӣ.CA125ڸӲеٴֵ[J].Ĵҽѧ,2012,(2):322-323.

[5],ⴺ,, .ʪؽ׻ CA125[J].лٴߺͱ̬Ӧ־,2015,(1):26-30.

 [6],ܾ,Ż, .HE4ƤѳеıٴԤĹϵ[J].֢չ,2018,(5):629-631,635.

[7]κ,԰԰,, .󳦰ѪHE4DKK-1ˮƽ仯[J].ɽҽҩ,2018,(27):26-29.

[8],,˧.ѪTK1CRPHE4CEAˮƽΰԤϵijʽо[J].ٴο־,2018,(2):224-227.

 
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